Time-effect of montelukast on protection against exercise-induced bronchoconstriction

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چکیده

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Can a single dose response predict the effect of montelukast on exercise-induced bronchoconstriction?

RATIONALE Exercise-induced bronchoconstriction (EIB) can be prevented by a single dose of montelukast (MLK). The effect is variable, similar to the variable responsiveness observed after daily treatment with MLK. We hypothesized that the effect of a single MLK-dose (5 or 10 mg) on EIB could predict the clinical effectiveness of longer term once daily treatment. METHODS This was a prospective,...

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Effect of montelukast or salmeterol added to inhaled fluticasone on exercise-induced bronchoconstriction in children.

OBJECTIVES To evaluate the effect of montelukast, 5 mg, or inhaled salmeterol, 50 microg, added to inhaled fluticasone in reducing the maximum percentage decrease in forced expiratory volume in 1 second (FEV1) after a standardized exercise challenge and response to rescue bronchodilation with albuterol in children aged 6 to 14 years with persistent asthma and exercise-induced bronchoconstrictio...

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Lack of tolerance to the protective effect of montelukast in exercise-induced bronchoconstriction in children.

The effect over time of regular treatment with montelukast (MNT) in inhibiting exercise-induced bronchoconstriction (EIB) has never been evaluated in children. The aim of the present study was to examine the preventive effect of MNT against EIB in children at different time-points over a 4-week treatment period. Thirty-two asthmatic children (aged 6-12 yrs) were enrolled in a double-blinded, ra...

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Effect of warm-up exercise on exercise-induced bronchoconstriction.

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ژورنال

عنوان ژورنال: Respiratory Medicine

سال: 2011

ISSN: 0954-6111

DOI: 10.1016/j.rmed.2011.08.007